|
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
WPMY-1 stromal cells expressing ps20 were characterised by transcriptome microarray and the function of WPMY-1 conditioned media on growth of PCa cell lines was assessed.
|
27115470 |
2016 |
|
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We, therefore, chose to examine WFDC1/ps20 for mutations and expression changes in prostate cancer.
|
15305342 |
2004 |
|
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The WFDC1 gene is frequently down-regulated or lost in prostate cancer, and the encoded protein, ps20, has been implicated in epithelial cell behaviour and angiogenesis.
|
30423385 |
2019 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The WFDC1 gene is frequently down-regulated or lost in prostate cancer, and the encoded protein, ps20, has been implicated in epithelial cell behaviour and angiogenesis.
|
30423385 |
2019 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We, therefore, chose to examine WFDC1/ps20 for mutations and expression changes in prostate cancer.
|
15305342 |
2004 |
|
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
WPMY-1 stromal cells expressing ps20 were characterised by transcriptome microarray and the function of WPMY-1 conditioned media on growth of PCa cell lines was assessed.
|
27115470 |
2016 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Modulated expression of WFDC1 during carcinogenesis and cellular senescence.
|
18842679 |
2009 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Enhanced expression of either WFDC1 or IL-17D potently represses SORBS2 depletion-mediated cancer metastasis promotion.
|
29548303 |
2018 |
|
Duane Retraction Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we show that ps20 mRNA synthesis is induced by TGF-beta1, a known regulator of endothelial cell-pericyte interactions and of stromal cell-induced angiogenesis in DRS tumors.
|
14522910 |
2003 |
|
Fibrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of WFDC1 inhibited the growth rate of the fibrosarcoma HT1080 cell line.
|
18842679 |
2009 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Quantitative RT-PCR demonstrated significant down regulation of WFDC1/ps20 in prostate tumors.
|
15305342 |
2004 |
|
Adult Fibrosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of WFDC1 inhibited the growth rate of the fibrosarcoma HT1080 cell line.
|
18842679 |
2009 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Enhanced expression of either WFDC1 or IL-17D potently represses SORBS2 depletion-mediated cancer metastasis promotion.
|
29548303 |
2018 |
|
melanoma
|
0.310 |
PosttranslationalModification
|
disease |
BEFREE |
Furthermore, we show that promoter hypermethylation accounts for the silencing of the WFDC1 gene in 20% of the melanoma cell lines examined.
|
19488830 |
2009 |
|
melanoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Epigenetic silencing of novel tumor suppressors in malignant melanoma.
|
17145863 |
2006 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Gene expression microarray analysis and further expression validation suggests that the Dickkopf-1 (Dkk1) gene is up-regulated in WFDC1 over-expressing cell lines, suggesting that the tumor suppressive function of WFDC1 may be partially a result of up-regulated Dkk1 gene expression, which is known to be a potent inhibitor of the Wnt signaling pathway.
|
19488830 |
2009 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
WFDC1/ps20 expression is frequently downregulated or lost in prostate cancer (PCa) and ps20 has demonstrated growth-suppressive functions in numerous tumour model systems, although the mechanisms of this phenomenon are not understood.
|
27115470 |
2016 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions.
|
14522910 |
2003 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We, therefore, propose that WFDC1/ps20 may not be a classical tumor suppressor gene, but might play a role in the maintenance of the normal extra cellular matrix milieu in the prostate.
|
15305342 |
2004 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
We further investigated the role of WFDC1 as a tumour suppressor gene candidate in five hepatocellular cell lines and in tumours exhibiting LOH by means of mutation, promoter methylation and gene expression analysis.
|
12032731 |
2002 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest an important role for WFDC1 in inhibiting proliferation of both tumors and senescent cells.
|
18842679 |
2009 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.
|
14522910 |
2003 |
|
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.
|
14522910 |
2003 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
To address the potential effects of ps20 in a tumor microenvironment, we used the DRS model to evaluate both angiogenesis and tumorigenesis of tumors generated under either ps20 or control conditions.
|
14522910 |
2003 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Identification and characterization of the WFDC1 gene may aid in better understanding the potential role of this gene and ps20 in prostate biology and carcinogenesis.
|
10967136 |
2000 |